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KMID : 0043319850080010021
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Archives of Pharmacal Research
1985 Volume.8 No. 1 p.21 ~ p.30
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Antimicrobial and Antineoplastic Tyrosine Metabolites from a Marine Sponge, Aplysina fistularis
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Goo YM
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Abstract
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Examination of the constituents of a marine sponge, Aplysina fistularis, indicated that brominated tyrosine metabolites were mainly responsible for antimicrobial and antineoplastic activities. Halogenated tyrosine metabolites, 2, 6-dibromo-(2), 2-bromo-3-chloro-(3) and 2, 6-dichloro-(4) 4-hydroxy-2,5-cyclohexadienone-4-acetamides,as well as the lactam derivatives, 5-amino-2,6-dibromo-(5), 5-amino-2-bromo-6-chloro-(6) and 5-amino-2,6-dichloro-(7) 4-hydroxy-2-cyclohexenone-4-acetic acid lactams were identified as the major antineoplastic and antimicrobial principles. Many other brominated tyrosine metabolites were also confirmed, but they did not show antimicrobial and antineoplastic activities.
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KEYWORD
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