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KMID : 0043319890120030196
Archives of Pharmacal Research
1989 Volume.12 No. 3 p.196 ~ p.200
Isolation of Hepatic Drug Metabolism Inhibitors from the Rhizomes of Curcuma zedoaria
Shin KH
Kim ON/Woo WS
Abstract
The methanolic extract of the Rhizome of Curcuma zedoaria exhibited a significant prolongation of hexobarbital (HB)-induced hypnosis. Through liquid chromatography of an ether soluble fraction, monitoring by bioassay, three sesquiterpenes, germacrone(A), curzerenone(B) and germacrone epoxide(C) were isolated as active constituents. A single treatment (100-200mg/kg, i.p.) of each compound showed not only a significant prolongation of HB-induced sleeping time but also a significant inhibition of aminopyrine N-demethylase activity in mice, and further exhibited a typical type I binding spectra with oxidized rat hepatic cytochrome P-450 induced by phenobarbital. All of the compounds provoked a sleep episode at a subhypnotic dose of HB, implying that they possess CNS depressant properties.
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