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KMID : 0043319900130010024
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Archives of Pharmacal Research
1990 Volume.13 No. 1 p.24 ~ p.27
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Thienobenzothiopyranones III New 4H-thieno[2,3-b][1]benzothiopyran-4-ones Carrying Different Heterocyclic Moieties of Expected Pharmacological Interest
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El Subbagh HI
El Emam AA/El Ashmawy MB/Shehata IA
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Abstract
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Reaction of 2-formyl-4H-thieno[2,3-b][1]benzothiopyran-4-one (1) with different heterocyclic amines afforded the corresponding Schiff’’s bases (2-4). Diethyl malonate, ethyl cyanoacetate and malononitrile were reacted with 1 to afford compounds 5, 7 and 8, respectively. Compound 5 was cyclized to the pyrazolidin-3,4-dione (6) by the action of hydrazine hydrate, whereas compound 7 was utilized for the synthesis of the thiazolin-4-one derivatives (9-13).
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