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KMID : 0043319900130020132
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Archives of Pharmacal Research
1990 Volume.13 No. 2 p.132 ~ p.135
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Antioxidant Activity of Resveratrol Closely Correlates with Its Monoamine oxidase-A Inhibitory Activity
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Han YN
Ryu SY/Han BH
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Abstract
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Polyhydroxystilbenes including resveratrol were reported to competitively inhibit monoamine oxidase-A without structural relation with substrates and synthetic inhibitors for the enzyme. We attempt to explore a plausible mechanism for their inhibitory activity on MAO-A. All the polyhydroxystilbenes tested showed the antioxidant activity on liver homogenate. Furthermore, the antioxidant activity turned out to closely correlate with the MAO-A inhibitory activity.
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