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KMID : 0043319900130020161
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Archives of Pharmacal Research
1990 Volume.13 No. 2 p.161 ~ p.165
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Mouse Thymocyte Cytolysis of Several Anti-inflammatory Steroid Derivatives
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Lee SH
Choi HP/Namgoong SY/Kim KH/Kim HP
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Abstract
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For evaluating the cytolytic effects on the mouse thymocytes, four typical anti-inflammatory steroids (dexamethasone, triamcinolone acetonide, prednisolone, hydrocortisone) were selected in this study. When steroids were treated to the mouse thymocytes in vitro cytolysis occurred with dose-dependent fashion and the activities were found to be parallel with the known local anti-inflammatory activities. In vivo thymus atrophogenic activities appeared by the treatment of topical and subcutaneous applications of the derivatives were also found to dose-dependent, but not coincided with the thymocyte cytolytic activities in vitro and local anti-inflammatory activity in the case of triamcinolone acetonide. Triamicinolone acetonide induced potent thymocyte cytolysis in vitro, but showed less thymus atrophy.
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