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KMID : 0043319940170020093
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Archives of Pharmacal Research
1994 Volume.17 No. 2 p.93 ~ p.99
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The Mechanism of Poly I:C-Induced Antiviral Activity in Peritoneal Macrophage
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Pyo Suhk-Neung
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Abstract
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Macrtophages play an important role in defense against virus infection by intrinsic resistance and by extrinsic resistance. Since interferon-induced enzymes which are 2’-5’ oligoadenylate synthetase and p1/eIF-2 protein kinase have been shown to be involved in the inhibition of viral replication, I examined the mechanism by which poly I:C, an interferon inducer, exerts its antiviral effects in inflammatory macrophages infected with herpes simplex virus type 1 (HSV-1). The data presented here demonstrate that poly I:C-induced antiviral activity is partially due to the activation of 2’-5’ pligoadenylate synthetase. The activation of 2’-5’ oligoadenlate A synthetase by poly I:C is also at least mediated via the production of interferon-.betha.. Taken together, these data indicate that interferon-.betha. produced in response to poly I:C acts in an autocrine manner to activate the 2’-5’ oligoadenylate synthetase and to induce resistance to HSV-1.
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KEYWORD
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Poly l:C, interferon, 2′-5′ oligoadenylate synthetase, Protein kinase
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