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KMID : 0043319940170030150
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Archives of Pharmacal Research
1994 Volume.17 No. 3 p.150 ~ p.153
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Cardiovascular Actions of Daucus carota
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Gilani A.H.
Shaheen F.
Saeed S.A.
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Abstract
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Ethanolic extract of Daucus carota (DC) at the dose of 10-100 mg/kg caused a dose-dependent fall in systolic and diastolic arterial blood pressure in nomotensive anesthetized rats. These effects were not blocked by atropine (1 mg/kg) and pretratment with DC did not alter the pressor response to norepinephrine indicating that cardiovascular effects of DC are independent of cholinergic or adrenergic recptors involvement. In spontaneously beating guinea-pig paired atria, DC induced a concentration-dependent (03-5 mg/ml) decrease in force and rate of atrial contractions. In rabbit thoracic aorta, DC caused inhibition of -induced contractions at similar concentrations. These results suggest that the extract may exhibit channel blocking-like direct relaxant action on cardiac and smooth muscle preperations and this action may be responsible for its hypotensive effect observed in the in vivo studies.
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KEYWORD
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Daucus carota, Hypotensive, Spasmolytic, In vivo, ln vitro
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