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KMID : 0043319940170040213
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Archives of Pharmacal Research
1994 Volume.17 No. 4 p.213 ~ p.217
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Testicular Degeneration and Sperm Loss Induced by Chronic Administration of CocaineiIn Mice
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Suh Jeong-Hye
Yang Boo-Keun
Lim Dong-Koo
Jhoo Wang-Kee
Kim Hyoung-Chun
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Abstract
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The effect of ccocaine on reproductive system were studied in male ICR mice. daily injection of cocaine HCL (10, and 40 mg/kg s.c for 15 days) disrupted epididymal sperm levels and testicular morphology. These disruptions were manifested in a decreased number of sperum, an increased number of dead sperm as compared with control vehicle, and wre evidenced by vacuolations, multinucleated giant cell formations and coagulation necrosis in the testicular seminiferous tubules. Responses in the current study were trended in dose dependent pattem. These results suggest that thronic cocaine intoxication can perturb on male reproductive organ functioning.
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KEYWORD
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Chronic cocaine intoxication, epididymal, sperm level, testicular morphololgy, coagulation, necrosis, reprocuctive organ functioning
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