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KMID : 0043319940170050304
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Archives of Pharmacal Research
1994 Volume.17 No. 5 p.304 ~ p.308
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KR-25018: A Novel, Orally Active Analgesic with Non-Narcotic Properties
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Lee Buyean
Kim Jae-Hong
Park No-Sang
Kong Jae-Yang
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Abstract
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Among the new series of phenylacetamides, one of capsaicin derivatives, KR-25018 was found to have a very potent analgesic activity. Thus, the phamacological properties of KR-25018 were compared with those of morphine, capsaicin, and nonsteroidal antiinflammatory drugs (NSAIDs). The analgesic activities were evaluated in several animal models, using different stimuli, such as phenylbenzoquinone(PBQ)-induced weithing test, tail-filck test in mice and adjuvant arthritic flexion test in rat. The relationship of phamacological properties of KR-25018 to that of centrally acting opioids was assessed by the blocking test using naloxone. The analgesic potency of the KR-25018 =0.61$ s.c. in tail-flick test in mice0, with different action mechanism from morphine and NSAIDs, was comparable to that of morphine.
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KEYWORD
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Capsaicin, KR-25018, Morphine, NSAIDs, Analgesic activity
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