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KMID : 0043319950180020079
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Archives of Pharmacal Research
1995 Volume.18 No. 2 p.79 ~ p.83
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Protective Roles of Mushrooms in Experimental Colon Carcinogenesis
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Kim Dong-Hyun
Jang Il-Sung
Park Jong-Baek
Lee Seung-Won
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Abstract
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There is epidemilogical evidence that the population with high fecal activity has greater risk of colon cancer than the population with low facal . This relationship was investigated by using the mouse-dimethylhydrazine colon carcinogenesis model and the fraction of Glucidum which is a .inhibitor. Mice with low facal activity induced by consumption of the ether fraction of G lucidum had significantly fewer aberrant crypts(AC) after injections of 1, 2-dimethylhydeazine (DMH) than mice treated with DMH alone. The result supports the hypothesis that the inhibitor such as the ether fraction of G lucidum can protect an animal against the induction of colon cancer.
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KEYWORD
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Mushroons, Colorectal cancer, Aberrant crypts
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