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KMID : 0043319950180030179
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Archives of Pharmacal Research
1995 Volume.18 No. 3 p.179 ~ p.182
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A Study for Regulation of Ethanol-inducible P450(CYP2E1) on CCI4-induced Hepatic Damage
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Park Sum-Mi
Park Eun-Jeon
Ko Geon-il
Kim Jae-Baek
Sohn Dong-Hwan
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Abstract
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Previous study showed that administration evoked a rapid decrease in cytochrome 2E1 protein soon after the exposure due to posttranslational inhibition(Biochem. Biophys. Res. Commun. 179:449-454, 1991). In this report, aniline hydroxylase and the amounts of immunoreactive 2E1 were rapidly decreased during day 1 to 2 and recovered during day 3 to 4 after a single dose of . The activity of pentoxyresorufin-O-dealkylase was also suppressed at day 1 and began to repair from day 2. However, the decrease in immunoreactive 2C content was not observed. The decreases in 2E1 enzyme activity and immunoreactive protein by acute treatment were accompanied by a decline in 2E1 mRNA level. The data thus suggested a pretranslational reduction of 2E1 during day 1 to 2 after acute treatment.
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KEYWORD
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Carbon tetrachloride, Cytochrome P450 2E1, Cytochrome P450 2C, Aniline hydroxylase, Pentoxyresorufin-O-dealkylase
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