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KMID : 0043319950180030185
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Archives of Pharmacal Research
1995 Volume.18 No. 3 p.185 ~ p.202
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Thio and Nitrogen Analogues of Acronycine
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Geewananda Y.A.
Gunawardana P.
Cordell Geoffrey A.
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Abstract
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The thio, thio acetyl, oxime, and several hydrazone and azine derivatives of the antitumor alkaloid acronycine (1) were prepared. NMR spectroscopy was used to study the configurations around the C=N double bond in these acronycine derivatives. In the hydrazones and azines of acronycine the N-N bond assumes a syn configuration to the group, while the NO bond in the oxime and the N-N bond in noracronycine hydrazone and azines assumes an anti configuration.
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KEYWORD
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Acronycine, Thio analogues, Nitrogen analogues, Configuration assignments
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