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KMID : 0043319950180050314
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Archives of Pharmacal Research
1995 Volume.18 No. 5 p.314 ~ p.319
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Dissolution Characteristics of ph-Dependent Antacid Granules Agglomerated in High Speed Agitation Type Speed Agitation Type Granulator
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Choi Woo-Sik
Lee Jung-Sun
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Abstract
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Antacid granules were prepared by agglomeration and powder method in high speed agitation type granulator. The copmositions of the test antacids were sodium bicarbonate nad magnesium carbonate nad a coating material was powder of polyvinylacetal diethyl-aminocacetate (AEA) and an additive material was talc powder. The dissolution characteristics of base from the antacid granules were investigated to evaluate neutralization capacity of hydrochloric profile of base and neutralization behavior, the following results were obtained : The prepared granules showed a pH-dependent dissolution pattern of a base. The dissolution profile of a base was varied with addition of talc powder as well as coating amount of AEA. The relationship between the ratio of dissolution retarded time for 20% and 10% AEA. The relationship between the ratio of dissolution retarded time for 20% AEA coated granules and the diameter reduction of the granules was explained by the rate process of neutralization of hydrochloric acid.
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KEYWORD
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Antacid, Polyvinylacetal diethylaminoacetate(AEA), pH-dependent dissolution
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