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KMID : 0043319960190010006
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Archives of Pharmacal Research
1996 Volume.19 No. 1 p.6 ~ p.11
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Cytotoxicity of Trichothecenes to Human Solid Tumor Cells in Vitro
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Choi Sang-Un
Choi Eun-Jung
Kim Kwang-Hee
Kim Nam-Young
Kwon Byoung-Mog
Kim Sung-Uk
Bok Song-Hae
Lee So-Young
Lee Chong-Ock
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Abstract
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The trichothecenes are sesquiterpenoid mycotoxins characterized by the 12,13-epoxytrichothec-9-ene ring system. We have tested cytotoxicity of several naturally-occurring or synthesized trichothecenes against human solid tumor cell lines. Among them, trichothecin(I) and -Acetoxy-12,13-epoxytrichothec-9-ene (trichodermin, II) exhibited highly cytotoxic activities. 4-.betha.-Hydroxy-12,13-epoxytrichothec-9-ene (trichodermol, III) and -Methoxy-12,13-epoxytrichothec-9-ene (IV) had mild cytotoxicities. But 12,13-Epoxytrichothec-9-ene-4-one (V) and -Hydroxy-12,13-epoxytrichothec-9-ene(VI) had no cytotoxicities up to 10 . And in the tested cell lines, HCT15 colon cancer cell line was the most sensitive to all tested trichothecenes.
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KEYWORD
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Trichothecenes, Gliocladium, Trichothecium, Cytotoxicity, Human tumor cell line
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