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KMID : 0043319960190040317
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Archives of Pharmacal Research
1996 Volume.19 No. 4 p.317 ~ p.320
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Bactericidal activities of LB20304, a new fluoroquinolone
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Paek Kyoung-Sook
Kim Mu-Yong
Kim In-Chull
Kwak Jin-Hwan
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Abstract
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The time-kill curves of LB20304, a novel fluoroquinolone that has potent antibacterial activity against gram-positve and gram-negative bacteria, were calculated at the concentrations of 1/4-, 1/2-, 1-, 2- and 4-times the MIC against Staphylococcus aureus 77, Escherichia coli 3739E, Pseudomonas aeruginosa 1912E. The bactericidal activity of LB20304 for these strains was very rapid and comparable to that of ciprofloxacin. LB20304 produced a decrease in the CFU per milliliter of3 within 2 h at 4-times the MIC for all strains and consitently prevented regrowth of bacteria after 24 h of incubation. The MBCs (Minimal Bactericidal Concentration) of LB20304 against test organisms were equal to or at most four-times higher than the MICs.
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KEYWORD
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LB-20304, Fluoroquinolone, Bactericidal activity, Time-kill, MBC
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