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KMID : 0043319960190060559
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Archives of Pharmacal Research
1996 Volume.19 No. 6 p.559 ~ p.561
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Isolation of a Cytotoxic Agent from Asiasari Radix
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Park Jong-Dae
Baek Nam-In
Lee You-Hui
Kim Shin-Il
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Abstract
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A minor cytotoxic compound was isolated by bioassay-guided fractionation from Asiasari Radix and identified as aristolactam III(1) on the basis of spectral data and chemical evidence. This is the first report on the isolation of compound 1 from Asiasarum genus. Compound 1 exhibited a significant cytotoxic activity against the three kinds of human cancer cell lines (A 549, SK-MEL-2 and SK-OV-3).
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KEYWORD
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Asiasari Radix, Aristolochiaceae, Aristolactam III, Cytotoxicity, Antitumor agent
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