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KMID : 0043319970200010058
Archives of Pharmacal Research
1997 Volume.20 No. 1 p.58 ~ p.67
Anti-herpetic Activity of Various Medicinal Plant Extracts
Woo Eun-Rhan

Kim Hyoung-Ja
Kwak Jong-Hwan
Lim Young-Kwern
Park Seong-Kyu
Kim Hae-Soo
Lee Chong-Kyo
Park Ho-Koon
Abstract
In order to find antiviral compounds against Herpes simplex virus type I (HSV-1) and II (HSV2) from natural products, a convenient virus-induced cytopathic effect (CPE) inhibition assay was introduced. More than 300 fractions were prepared by solvent fractionation from sixty collected plants or purchased herbal medicines, and their anti-herpetic activities were evaluated. Among them, several medicinal plants showed potent anti-herpetic activity. Selective indexes (SI) of the EtOAc extract of Caraganae Radix (Caragana sinica) against HSV-1 and HSV-2 were more than 8.06 and 24.79, SI of the MeOH extract of Acer okamotoanum leaves were 3.92 and 3.51, SI of the extract of Veratri Rhizoma et Radix (Veratrum patulum) were 5.49 and 1.31 and SI of the MeOH extract of aerial part of Osmundae Rhizoma (Osmunda japonica) were more than 3.45 and 1.25, respectively.
KEYWORD
Antivirals, Natural products, Screening, Herpes simplex virus type I, II, Seletive index (SI)
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