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KMID : 0043319970200010085
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Archives of Pharmacal Research
1997 Volume.20 No. 1 p.85 ~ p.87
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Cytotoxic Constituents of Sorbaria sorbifolia var. stellipila
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Kim Dae-Keun
Choi Sang-Hoon
Lee Jung-Ock
Ryu Shi-Yong
Park Dae-Kyu
Shin Dae-Hee
Jung Jee-Hyung
Pyo Suhk-Keung
Lee Kang-Ro
Zee Ok-Pyo
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Abstract
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The activity-guided fractionation upon the MeOH extract of the aerial parts of Sorbaria sorbifolia var. stellipila led to the isolation of two cucurbitacin-compounds, cucurbitacin D and cucurbitacin F, as active principles. Two compounds were shown to exhibit significant cytotoxicity against cultured human tumor cell lines, A-549, SK-OV-3, SK-MEL-2, XF-498, and HCT 15.
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KEYWORD
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Sorbaria sorbifolia var. stellopila, Cucurbitacin D, Cucurbotacin F, Cytotoxicity
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