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KMID : 0043319970200020158
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Archives of Pharmacal Research
1997 Volume.20 No. 2 p.158 ~ p.170
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Synthesis and biological activity of 4,5-polymethylenepyrazole-derived HMG-CoA reductase inhibitors
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Kim Jin-Il
Choi Young-Hee
Jahng Yurng-Dong
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Abstract
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New HMG-CoA reductase inhibitors, in which 3-substituted 4, 5-polymethylenepyrazoles are employed as a hydrophobic anchor connected to tetrahydro-4-hydroxy-2H-pyran-2-one by a two-carbon bridge, were designed and synthesized to exhibit significant inhibitory activity comparable to mevinolin. The most potent enzyme inhibitor is 4-fold more potent than lovastatin.
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KEYWORD
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HMG-CoA reductase inhibitor, 3-Substituted 4, 5-polymethylenepyrazole
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