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KMID : 0043319970200040342
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Archives of Pharmacal Research
1997 Volume.20 No. 4 p.342 ~ p.345
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A Cytotoxic Constituent from Sophora flavescens
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Kim Youn-Kwan
Min Byung-Sun
Bae Ki-Hwan
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Abstract
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A cytotoxic constituent was isolated by bioassay-guided procedure from the roots of Sophora flavescens Aiton (Leguminosae). The constituent was identified as sophoraflavanone G (I) by means of chemical methods and in comparsion with spectral data of standard compound. The values of constituent I were 0.78, 1.57, 2.14 and against A549, HeLa, K562 and L1210 cell lines, respectively. Constituent I exhibited highly cytotoxic activities against A549, K562 and HeLa cells, but showed a mild activity against L1210 cells. Among the tested cell lines, A549 cells were the most sensitive to constituent I.
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KEYWORD
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Sophora flavescens, Sophora moorcroftiang, Leguminosae, sophoraflavanone G:cytotoxicity, A549
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