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KMID : 0043319970200050420
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Archives of Pharmacal Research
1997 Volume.20 No. 5 p.420 ~ p.424
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Metabolism of Saikosaponin c and Naringin by Human Intestinal Bacteria
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Yu Ki-Ung
Jang Il-Sung
Kang Keung-Hyung
Sung Chung-Ki
Kim Dong-Hyun
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Abstract
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By human intestinal bacteria, saikosaponin c was transformed to four metabolites, prosaikogenin E1 (E1) prosaikogenin E2 (E2), prosaikogenin E3 (E3) and saikogenin E. Metabolic time course of saikosaponin c was as follows; in early time, saikosaponin c was converted to E1 and E2, and then these were transformed to saikogenin E via E3. Also, this metabolic pathway was similar to the metabolism of saikosaponin c by rat intestinal bacteria. Bacteroides JY-6 and Bacteroides YK-4, the bacteria isolated from human intestinal bacteria, could transform saikosaponin c to E via E1 (or E2) and E3. However, these bacteria were not able to directly transform El and E2 to saikogenin E. Naringin was mainly transformed to naringenin by human intestinal bacteria. The minor metabolic pathway transformed naringin to naringenin via prunin. By JY-6 or YK-4, naringin was metabolized to naringenin only via prunin.
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KEYWORD
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Bacteroides spp, Saikosaponin c, Naringin, Intestinal bacteria
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