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KMID : 0043319970200050507
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Archives of Pharmacal Research
1997 Volume.20 No. 5 p.507 ~ p.509
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Synthesis of novel Heterocycles Through Reaction of Indolin-2-one Derivatives with Active Methylene and Amino Reagents
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Abdel-Latif F.F.
Ahmed E.Kh.
Mekheimer R.
Mashaly M.M.
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Abstract
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Several new spiro compounds were synthesized via one-pot ternary condensation of isatin, malononitrile and each of thiobarbituric acid, barbituric, 3-methyl-pyrazolin-5-one, 1-phenyl-3-methyl-pyrazolin-5-one, acetylacetone, benzoylacetone, ethyl acetoacetate, phenacyl cyanide or ethyl-cyanoacetate dimer. Structures and reaction mechanisms were reported and supported via a second synthetic route.
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KEYWORD
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Heterocycles, indolin-2-one, Malononitrile, Methylene and amino reagents
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