Àá½Ã¸¸ ±â´Ù·Á ÁÖ¼¼¿ä. ·ÎµùÁßÀÔ´Ï´Ù.
KMID : 0043319970200060560
Archives of Pharmacal Research
1997 Volume.20 No. 6 p.560 ~ p.565
Solubility and Stability of Melatonin in Propylene glycol and 2-hydroxypropyl--cyclodextrin vehicles
Lee Beom-Jin

Choi Han-Gon
Kim Chong-Kook
Parrott Keith-A.
Ayres James-W.
Sack Robert-L.
Abstract
The physicochemical properties of melatonin (MT) in propylene glycol (PG) and 2-hydroxypropyl-.betha.-cyclodextrin vehicles were characterized. MT was endothermally decomposed as determined by differential scanning calorimetry (DSC). Melting point and heat of fusion obtained were .and ., respectively. MT as received from a manufacture was very pure, at least 99.9%. The solubility of MT in PG solution increased slowly until reaching 40% PG and then steeply increased. Solubility of MT increased linearly as concentration of without PG INCREASED. MT solubility in the mixtures of pg and also increased linearly but was less than the sum of its solubility in and PG individually. The MT solubility was low in water, simulated gastric or intestinal fluid but the highest in the mixture of PG(40v/v%) and (30w/v%) although efficiency of MT solubilization in decreased as the concentration of PG increased. MT was degraded in a fashion of the first order kinetics $(r^2>0.90)$. MT was unstable in strong acidic solution (HCl-NaCl buffer, pH 1.4) but relatively stable in other pH values of 4-10 at . In HCl-NaCl buffer, MT in 10% PG was more quickly degraded and then slowed dpwm at a higher concentration. However, the degradation rate constant of MT in 2-HP.betha.CD was not changed significantly when compared to the water. The current studies can be applied to the dosage formulations for the purpose of enhancing percutaneous absorption or bioavailability of MT.
KEYWORD
Melatonin, Solubility, Stability, Propylene glycol, 2-Hydroxypropyl-b-cyclodextrin
FullTexts / Linksout information
Listed journal information
SCI(E) MEDLINE ÇмúÁøÈïÀç´Ü(KCI)