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KMID : 0043319980210030330
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Archives of Pharmacal Research
1998 Volume.21 No. 3 p.330 ~ p.337
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Reactivity and Suitability of t-Boc-protected Thiophosphotyrosine Intermediate Analogs for the Solid or Solution Phase Peptide Synthesis
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Kim Eun-Kyung
Choi Hee-Sung
Lee Eung-Seok
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Abstract
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N-(tert-Butoxycarbonyl)-O-(dimethythiophosphono)-L-tyrosine (6) and N-(tert-butoxycarbonyl)-O-(dicyanoethylthiophosphono)-L-tyrosine (15) were prepared as intermediates for the synthesis of thiophosphotyrosine-containing peptides. The reactivity and suitability of two compounds for the solid phase or solution phase peptide synthesis utilizing t-Boc chemistry were examined.
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KEYWORD
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Thiophosphotyrosine, Phosphotyrosine, Protein tyrosine kinase(PTK), Peptide synthesis, Cyanoethyl protection
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