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KMID : 0043319980210040406
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Archives of Pharmacal Research
1998 Volume.21 No. 4 p.406 ~ p.410
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A new Potential Anti-inflammatory Agent
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Kim Hee-Kee
Son Kun-Ho
Chang Hyun-Wook
Kang Sam-Sik
Kim Hyun-Pyo
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Abstract
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Biflavonoid is one of unique classes of naturally-occurring bioflavonoids. Certain biflavonoids including amentoflavone were previously reported to have inhibitory effect on the group 11 phospholipase activity. Amentoflavone was also found to inhibit cyclooxygenase from guinea-pig epidermis without affecting lipoxygenase. In this study, anti-inflammatory and analgesic activities of amentoflavone were evaluated. When amentoflavone was administered intraperitoneally, it showed a potent anti-inflammatory activity as determined by amelioration of croton-oil induced mouse ear edema. It also showed a potent anti-inflammatory activity in the rat carrageenan paw edema model (=42 mg/kg) compared to the activity of prednisolone (35 mg/kg) and indomethacin (10 mg/kg). However, amentoflavone did not show a significant inhibitory activity against rat adjuvant-induced arthritis, a chronic inflammatory model. In addition, amentoflavone was found to possess a potent analgesic activity in the acetic acid writhing test (=9.6 mg/kg) compared to the activity of indomethacin (3.8 mg/kg). These results suggest that amentoflavone may be a potential lead for a new type of anti-inflammatory agents having dual inhibitory activity of group 11 phospholipase and cyclooxygenase.
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KEYWORD
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Amentoflavone, Flavonoid, Biflavonoid, Anti-inflammatory activity, Analgesic activity, Phospholipase A2, Cyclooxygenase
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