KMID : 0043319980210040406
|
|
Archives of Pharmacal Research 1998 Volume.21 No. 4 p.406 ~ p.410
|
|
A new Potential Anti-inflammatory Agent
|
|
Kim Hee-Kee
Son Kun-Ho Chang Hyun-Wook Kang Sam-Sik Kim Hyun-Pyo
|
|
Abstract
|
|
|
Biflavonoid is one of unique classes of naturally-occurring bioflavonoids. Certain biflavonoids including amentoflavone were previously reported to have inhibitory effect on the group 11 phospholipase activity. Amentoflavone was also found to inhibit cyclooxygenase from guinea-pig epidermis without affecting lipoxygenase. In this study, anti-inflammatory and analgesic activities of amentoflavone were evaluated. When amentoflavone was administered intraperitoneally, it showed a potent anti-inflammatory activity as determined by amelioration of croton-oil induced mouse ear edema. It also showed a potent anti-inflammatory activity in the rat carrageenan paw edema model (=42 mg/kg) compared to the activity of prednisolone (35 mg/kg) and indomethacin (10 mg/kg). However, amentoflavone did not show a significant inhibitory activity against rat adjuvant-induced arthritis, a chronic inflammatory model. In addition, amentoflavone was found to possess a potent analgesic activity in the acetic acid writhing test (=9.6 mg/kg) compared to the activity of indomethacin (3.8 mg/kg). These results suggest that amentoflavone may be a potential lead for a new type of anti-inflammatory agents having dual inhibitory activity of group 11 phospholipase and cyclooxygenase.
|
|
KEYWORD
|
|
Amentoflavone, Flavonoid, Biflavonoid, Anti-inflammatory activity, Analgesic activity, Phospholipase A2, Cyclooxygenase
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|