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KMID : 0043319980210040418
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Archives of Pharmacal Research
1998 Volume.21 No. 4 p.418 ~ p.422
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Clonazepam Release from Poly(DL-lactide-co-glycolide) Nanoparticles Prepared by Dialysis Method
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Nah Jae-Woon
Paek Yun-Woong
Jeong Young-Il
Kim Dong-Woon
Cho Chong-Su
Kim Sung-Ho
Kim Myung-Yul
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Abstract
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Aim of this work is to prepare poly(DL-lactide-co-glycolide) (PLGA) nanoparticles by dialysis method without surfactant and to investigate drug loading capacity and drug release. The size of PLGA nanoparticles was 269.9 118.7 nm in intensity average and the morphology of PLGA nanoparticies was spherical shape from the observation of SEM and TEM. In the effect of drug loading contents on the particle size distribution, PLGA nanoparticles were monomodal pattern with narrow size distribution in the empty and lower drug loading nanoparticles whereas bi- or trimodal pattern was showed in the higher drug loading ones. Release of clonazepam from PLGA nanoparticles with higher drug loading contents was slower than that with lower loading contents.
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KEYWORD
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Poly(DL-lactide-co-glycolide), Nanoparticle, Dialysis method, Clonazepam, Controlled release
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