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KMID : 0043319990220020208
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Archives of Pharmacal Research
1999 Volume.22 No. 2 p.208 ~ p.212
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Cytotoxic Constituents form the Roots of Anthriscus sylvestris
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Lim Young-Hee
Leem Moon-Jeong
Shin Dong-Hyuk
Chang Hwan-Bong
Hong Seung-Woo
Moon Eun-Yi
Lee Dug-Keun
Yoon Sung-June
Woo Won-Sick
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Abstract
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Activity-guided fractionation of the roots of Anthriscus sylvestris resulted in the isolated and characterization of five cytotoxic compounds, deoxypodophyllotoxin (1), falcarindiol (2), and angeloyl podophyllotoxin (5) from the hexane soluble fraction and morelensin (3), bursehernin (4) from the choloroform soluble fraction. It is the first report of the occurrence of compound 5 in nature.
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KEYWORD
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Anthriscus sylvestis, Anti-tumor agents, Cytotoxic lignans, Angeloyl podophyllotoxin
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