|
KMID : 0043319990220020225
|
|
Archives of Pharmacal Research
1999 Volume.22 No. 2 p.225 ~ p.227
|
|
|
A New Cytotoxic Acyclic Diterpene from Carpesium divaricatum
|
|
Zee Ok-Pyo
Kim Dae-Keun
Choi Sang-Un
Lee Chong-Ock
Lee Kang-Ro
|
|
|
Abstract
|
|
|
|
A new acylcic deterpene (1) and a known acyclic diterpene 12(S)-hydroxygeranyleraniol (2) were isolated form the aerial parts of Carpesium divaricatum. The structure of 1 was determined to be (2E, 10E)-1, 12-dihydroxy-18-acetoxy-3,7,15-trimethylhexadeca-2,10,14-triene (1) on the basis of spectroscopic studies. Compounds 1 and 2 exhibited cytotoxicity against cultured human tumor cell lines, A549, SK-OV-3, SK-MEL-2, XF498, and , with values ranging from 4.3-10.2 and 4.1-8.3 , respectively.
|
|
|
KEYWORD
|
|
|
Carpesium divaricatum, Acyclic diterpene, Cytotoxicity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|