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KMID : 0043320030260121061
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Archives of Pharmacal Research
2003 Volume.26 No. 12 p.1061 ~ p.1066
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Anti-Inflammation Activity of Actinidia polygama
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Kim Yoo-Kyung
Kang Hyo-Joo
Lee Kyung-Tae
Choi Jin-Gyu
Chung Sung-Hyun
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Abstract
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The fruit of Actinidia polygama (AP) has long been used as a folk medicine in Korea for treating pain, rheumatic arthritis and inflammation. The present investigation was carried out to determine the in vivo and in vitro anti-inflammatory activity of AP using several animal models of inflammation. The 70% ethanol extract of the fruit of AP significantly inhibited acetic acidinduced, vascular permeability in a dose dependent manner (23%, 38%, and 41 % inhibition at doses of 200 mg/kg, 500 mg/kg and 1000 mg/kg, respectively). This effect was maintained in AP water-soluble fraction (APW). The APW fraction also showed significant inhibitory activity against the rat paw edema induced by a single treatment of carrageenan. In vitro experiments were performed to demonstrate the inhibitory activities of APW (100 g/ml) on lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin () production. The results showed that APW dose-dependently suppressed LPS-induced NO production in RAW 264.7 macrophages without a notable cytotoxic effect and also decreased inducible NO synthase (iNOS) protein expression. APW also showed a significant inhibitory effect in LPS-induced production and cyclooxygenase-2 (COX-2) expression.
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KEYWORD
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Actinidia polygama, Anti-inflammation, Vascular permeability, Carrageenan, LPS, iNOS, COX-2
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