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KMID : 0043320050280101156
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Archives of Pharmacal Research
2005 Volume.28 No. 10 p.1156 ~ p.1160
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Iridoid Glycosides Isolated from Oldenlandia diffusa Inhibit LDL-Oxidation
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Kim Dong-Hyun
Lee Hyo-Jung
Oh Young-Jun
Kim Min-Jung
Kim Sung-Hoon
Jeong Tae-Sook
Baek Nam-In
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Abstract
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An iridoid glycoside, oldenlandoside III (5) was isolated from then-butanol fraction of methanol extracts of the aerial parts ofOldenlandia diffusa Roxb, along with six others previously characterized iridoid glycosides; geniposidic acid (1), scandoside (2), feretoside (3), 10-O-benzoylscandoside methyl ester (4), asperulosidic acid (6) and deacetylasperulosidic acid (7). Compounds1, 2, and7 inhibited LDL-oxidation, and showed 63.3±2.0, 62.2±1.6, and 63.8±1.5% inhibition, respectively, at a concentration of 20 μg/mL.
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KEYWORD
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Oldenlandia diffusa, Rubiaceae, Iridoid, Oldenlandoside III, LDL-Oxidation inhibition
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