|
KMID : 0043320060290070541
|
|
Archives of Pharmacal Research
2006 Volume.29 No. 7 p.541 ~ p.547
|
|
|
Cytotoxicity and DNA Topoisomerase Inhibitory Activity of Constituents Isolated from the Fruits of Evodia officinalis
|
|
Xu Ming-Lu
Li Gao
Moon Dong-Cheul
Lee Chong-Soon
Woo Mi-Hee
Lee Eung-Seok
Jahng Yurng-Dong
Chang Hyun-Wook
Lee Seung-Ho
Son Jong-Keun
|
|
|
Abstract
|
|
|
|
Four alkaloids (1-4), three quinolone alkaloids (5-7), and three flavanoid glucosides (8-10) were isolated from the fruits of Evodia officinalis Dode, and their structures were determined from chemical and spectral data. Compounds, 3, 8, 9 and 10 were isolated from this plant for the first time. Of these compounds, 1-3 and 5-7 exhibited moderate cytotoxicities against cultured human colon carcinoma (HT-29), human breast carcinoma (MCF-7), and human hepatoblastoma (HepG-2). Compound 8 showed strong inhibitory effects on DNA topoisomerases I and II (70 and 96% inhibition at a concentration of 20 μM, respectively).
|
|
|
KEYWORD
|
|
|
Evodia officinalis, DNA topoisomerases I and II inhibitors, Cytotoxicity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|