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KMID : 0043320060290110963
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Archives of Pharmacal Research
2006 Volume.29 No. 11 p.963 ~ p.968
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The Protective Effects of Phenolic Constituents from Gastrodia elata on the Cytotoxicity Induced by KCI and Glutamate
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Huang Zhan-Bo
Wu Zhe
Chen Fa-Kui
Zou Li-Bo
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Abstract
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Seven phenolic compounds (1-7) were isolated from the tubers of Gastrodia elata. Their structures were elucidated on the basis of MS and NMR spectral data. p-Ethoxymethyl phenyl-O--D-glucoside (1) was proved to be a new compound, with N-(p-hydroxybenzyl)-adenosine (7) isolated from this plant for the first time. In this study, the protective effects of the six constituents (1-6) on PC12 cells against the cytotoxicity induced by KCI and glutamate were also investigated. The viability of the PC12 cells was significantly enhanced by pretreatment with the six phenolic constituents.
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KEYWORD
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Gastrodia elata, Phenolic constituents, Neuroprotection, PC12 cells, MTT assay
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