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KMID : 0043320070300020151
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Archives of Pharmacal Research
2007 Volume.30 No. 2 p.151 ~ p.154
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Cytotoxic Isoquinoline Alkaloids from the Aerial Parts of Corydalis incisa
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Choi Sang-Un
Baek Nam-In
Kim Sung-Hoon
Yang Jae-Heon
Eun Jae-Soon
Shin Tae-Yong
Lim Jong-Pil
Lee Jae-Hyeok
Jeon Hoon
Yun Mi-Young
Leem Kang-Hyun
Park Hee-Wook
Kim Dae-Keun
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Abstract
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Three known isoquinoline alkaloids were isolated from the chloroform-soluble fraction of the methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) through repeated column chromatography. Their chemical structures were elucidated as corynoline (1), corynoloxine (2) and 6-oxocorynoline (3) using spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2 and HCT15 tumor cells.
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KEYWORD
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Corydalis incisa, Papaveraceae, Isoquinoline alkaloids
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