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KMID : 0043320070300101179
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Archives of Pharmacal Research
2007 Volume.30 No. 10 p.1179 ~ p.1185
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A New Monoterpene Glycoside from the Roots of Paeonia lactiflora Increases the Differentiation of Osteoblastic MC3T3-E1 Cells
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Yen Pham Hai
Kiem Phan-Van
Nhiem Nguyen Xuan
Tung Nguyen Huu
Quang Tran Hong
Minh Chau Van
Kim Jung-Woo
Choi Eun-Mi
Kim Young-Ho
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Abstract
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A new monoterpene glycoside, 6’-O-β-D-glucopyranosylalbiflorin (1), and four known compounds; albiflorin (2), 6’-O-benzoylalbiflorin (3), paeoniflorin (4) and benzoyl paeoniflorin (5), were isolated from the methanolic extract of the roots of Paeonia lactiflora Pall.. Their chemical structures were completely elucidated using a combination of 2D NMR techniques (COSY, HMQC and HMBC) and HRESI-MS analyses. To investigate the bioactivities of these compounds, their effects on the differentiation of osteoblastic MC3T3-E1 cells were tested. Compound 1 (0.01-10 μM) significantly increased the alkaline phosphatase activity and nodules mineralization of MC3T3-E1 cells compared to those of the control (P<0.05). These results suggest that newly isolated compound 1 has a direct stimulatory effect on bone formation in vitro and may contribute to the prevention for osteoporosis
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KEYWORD
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Paeonia lactiflora, 6-O-β-D-glucopyranosylalbiflorin, Osteoblast
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