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KMID : 0043320070300111464
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Archives of Pharmacal Research
2007 Volume.30 No. 11 p.1464 ~ p.1470
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Inhibition of Human Ovarian Tumor Growth by Cytokine-induced Killer Cells
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Kim Hwan-Mook
Kang Jong-Soon
Lim Jae-Seung
Park Song-Kyu
Lee Ki-Houn
Yoon Yeo-Dae
Lee Chang-Woo
Lee Ki-Hoon
Han Gyoon-Hee
Yang Kyu-Hwan
Kim Yeon-Jin
Han Sang-Bae
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Abstract
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Despite the recent improvement in the treatment of ovarian cancer, this disease is still leading cause of cancer death in women. In this study, the anti-tumor activity of cytokine-induced killer (CIK) cells against human ovarian cancer was evaluated in vitro and in vivo. Although CD3+CD56+ cells were rare in fresh human peripheral blood mononuclear cells, they could expand more than 1,000-fold on day 14 in the presence of anti-CD3 antibody plus IL-2. At an effector-target cell ratio of 30:1, CIK cells destroyed 45% of SK-OV-3 human ovarian cancer cells, which was determined by the 51Cr-release assay. In addition, CIK cells at a dose of 23 million cells per mouse inhibited 73% of SK-OV-3 tumor growth in nude mouse xenograft assay. This study suggests that CIK cells may be used as an adoptive immunotherapy for patients with ovarian cancer.
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KEYWORD
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Cytokine-induced killer cells, Ovarian cancer, Adoptive immunotherapy
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