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KMID : 0043320080310030294
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Archives of Pharmacal Research
2008 Volume.31 No. 3 p.294 ~ p.299
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Melanogenesis Inhibitory Compounds from Saussureae Radix
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Choi Ji-Young
Choi Eun-Hyang
Jung Hee-Wook
Oh Joon-Seok
Lee Won-Hee
Lee Jong-Koo
Son Jong-Keun
Kim Young-Soo
Lee Seung-Ho
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Abstract
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Ten compounds were isolated from the EtOAc soluble part of the MeOH extract of Saussureae Radix, with their effects on melanin production also evaluated in B-16 mouse melanoma cell lines stimulated with 3-isobutyl-1-methylxanthine (IBMX), an elevator of cellular cAMP. The compounds were identified as aplotaxene (1), 1-hydroxy arbusculin A (2), costunolide (3), dehydrocostuslactone (4), 11,13-dihydrocostunolide (5), reynosin (6), heptadec-(9Z)-enoic acid (7), -sitosterol (8), linoleic acid methyl ester (9) and betulinic acid methyl ester (10). Compounds 2, 9 and 10 were identified from Saussureae Radix for the first time. Furthermore, compounds 2, 3 and 6 showed potent inhibitory effects on the IBMX-induced melanogenesis, in dose-dependent manners, with values of 11, 3 and 2.5 , respectively. As a positive control, arbutin exhibited an value of 29 .
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KEYWORD
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Saussureae Radix, Melanogenesis, 1, -hydroxy arbusculin A, Costunolide, Reynosin
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