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KMID : 0043320080310050611
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Archives of Pharmacal Research
2008 Volume.31 No. 5 p.611 ~ p.616
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Cytotoxic Activities of Trichothecenes Isolated from an Endophytic Fungus Belonging to Order Hypocreales
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Chinworrungsee Maneekarn
Wiyakrutta Suthep
Sriubolmas Nongluksna
Chuailua Phitaya
Suksamrarn Apichart
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Abstract
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Bioassay-guided fractionation of the extract of the endophytic fungus KLAR 5 belonging to order Hypocreales, which was isolated from the twig of Knema laurina (Blume) Warb., resulted in the isolation of brefeldin A (1), 8-deoxy-trichothecin (2), trichothecolone (3), -hydroxytrichodermol (4), and -hydroxyscirpene (5). Compound 5 was isolated from natural source for the first time. Compound 1 was very highly active against human epidermoid carcinoma of the mouth, human breast cancer (BC-1), and human small cell lung cancer (NCI-H187) cells whereas compounds 2 and 4 were selectively active against BC-1 and NCI-H187 cells. Compounds 3 and 5 were moderately active against these three cancer cell lines.
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KEYWORD
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Endophytic fungus, Knema laurina (Blume) Warb., Trichothecene, Cytotoxicity
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