|
KMID : 0043320080310050653
|
|
Archives of Pharmacal Research
2008 Volume.31 No. 5 p.653 ~ p.658
|
|
|
In Vivo Anti-Inflammatory Effect of a New Steroidal Saponin, Mannioside A, and Its Derivatives Isolated from Dracaena mannii
|
|
Tapondjou Leon Azefack
Ponou Kemvoufo Beaudelaire
Teponno Remy Bertrand
Mbiantcha Marius
Djoukeng Jules Desire
Nguelefack Telesphore Benoit
Watcho Pierre
Cadenas Aurelio Gomez
Park Hee-Juhn
|
|
|
Abstract
|
|
|
|
A new steroidal saponin, mannioside A (1), was isolated from the stem bark of Dracaena mannii, together with the known pennogenin (2), pennogenin-3-O--D-glucopyranoside (3) and pennogenin-3-O--L-rhamnopyranosyl-()-[-L-rhamnopyranosyl-()]--D-glucopyranoside (4). Their structures were determined using 1D- and 2D-NMR spectroscopy and mass spectrometry. Compounds 1 and 3 significantly inhibited carrageenan-induced paw edema in the rat; compound 4 was moderately active whereas 2 showed very weak activity.
|
|
|
KEYWORD
|
|
|
Dracaena mannii, Mannioside A, Steroid saponin, Anti-inflammatory
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|