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KMID : 0043320090320010007
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Archives of Pharmacal Research
2009 Volume.32 No. 1 p.7 ~ p.13
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Anti-inflammatory Phenylpropanoid Glycosides from Clerodendron trichotomum Leaves
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Whang Wan-Kyunn
Ham In-Hye
Chung Min-Young
Kim Sun--Gun
Kim Gyoung-Hui
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Abstract
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The chromatographic separation of MeOH extract from Clerodendron trichotomum Thunberg leaves led to the isolation of three phenylpropanoid compounds. Using spectroscopic methods, the structures of these compounds were determined as β-(3’, 4’-dihydroxyphenyl)ethyl-O-α-L-rhamnopyranosyl (1→3)-β-D-(4-O-caffeoyl)-glucopyranoside, acteoside (verbascoside) (1), β-(3’, 4’-dihydroxyphenyl)ethyl-O- α-L-rhamnopyranosyl (1→3)-β-D-(6-O-caffeoyl)-glucopyranoside, isoacteoside (2), β-(3’, 4’-dihydroxyphenyl) ethyl-O-α-L-rhamnopyranosyl (1→3)-β-D-glucopyranoside, and decaffeoylacteoside (3). We measured the anti-inflammatory activity of these three phenylpropanoid compounds both in vitro (DPPH Reduction Assay, TBARS Assay on Cu 2+-induced oxidized LDL, PGE2 assay) and in vivo (acetic acidinduced vascular permeability in mice and carrageenan-induced hind paw edema in rats). 80% methanol fraction and acteoside had the activity.
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KEYWORD
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Clerodendron trichotomum, Verbenaceae, Acteoside, Verbascoside, Isoacteoside, Decaffeoylacteoside, Anti-inflammatory activity
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