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KMID : 0043320090320020191
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Archives of Pharmacal Research
2009 Volume.32 No. 2 p.191 ~ p.194
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An Oxepinoflavone from Artocarpus elasticus with Cytotoxic Activity Against P-388 Cells
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Ghisalberti Emilio L.
Latip Jalifah
Hakim Euis H.
Syah Yana M.
Juliawaty Lia D.
Musthapa Iqbal
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Abstract
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A new oxepinoflavone, artoindonesianin E1 (1), was isolated from the wood of Artocarpus elasticus,along with four known prenylated flavones: artocarpin (2), cycloartocarpin (3), cudraflavones A (4) andC (5). The structure of the new compound was identified by spectroscopic methods. Upon cytotoxic evaluation against murine leukemia P-388 cells, the new compound showed IC50 5.0 μg/mL.
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KEYWORD
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Artocarpuselasticus, Flavonoids, Oxepinoflavone, ArtoindonesianinE1, Cytotoxicity, P-388 cells
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