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KMID : 0043320090320020289
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Archives of Pharmacal Research
2009 Volume.32 No. 2 p.289 ~ p.294
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Inhibitory Effects of 6-(3-Hydroxyphenyl)-2-naphthol on Tyrosinase Activity and Melanin Synthesis
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Chung Hae-Young
Kim You-Jung
Suh Hong-Suk
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Abstract
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As a part of an ongoing project searching for new skin-lightening agents, the inhibitory property of 6- (3-Hydroxyphenyl)-2-naphthol (HPN) on melanogenesis was investigated. The inhibitory action of HPN (IC50=15.2 μM) on mushroom tyrosinase was revealed. To further explore the action of HPN on melanogenesis, the inhibition of tyrosinase and melanin levels were measured in B16 melanoma cells (B16 cells). Results show that HPN inhibited tyrosinase activity and reduced melanin in B16 cells. Therefore, our data indicate HPN as a new candidate for depigmentation reagents.
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KEYWORD
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6-(3-Hydroxyphenyl)-2-naphthol, Melanin, Melanogenesis, Tyrosinase
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