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KMID : 0043320090320060845
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Archives of Pharmacal Research
2009 Volume.32 No. 6 p.845 ~ p.849
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Bioactive Triterpenoids from Callistemon lanceolatus
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Lee Dong-Ho
Hwang Bang-Yeon
Lee Chul
Shin Yoo-Su
Yang Young-Taek
Kim Na-Hyun
Hong Seong-Su
Jeong Won-Sik
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Abstract
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A new triterpenoid, 30-hydroxyalphitolic acid 1, and eight known triterpenoids, alphitolic acid 2, lupenol 3, 3-acetoxy-olean-18-en-28-oic acid 4, betulinic acid 5, ursolic acid 6, betulinic acid 3-O-caffeate 7, morolic acid 3-O-caffeate 8, and ursolic acid 3-O-caffeate 9, were isolated from Callistemon lanceolatus. Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. All compounds were evaluated for the inhibition of LPSinduced nitric oxide production in murine macrophage RAW264.7 cells. Betulinic acid 3-O-caffeate 7 showed a moderate inhibitory effect on nitric oxide production with IC50 value of 15.4 μM.
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KEYWORD
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Callistemon lanceolatus, Myrtaceae, Triterpenoids, Betulinic acid 3-O-caffeate, NO production inhibitor
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