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KMID : 0043320090320081109
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Archives of Pharmacal Research
2009 Volume.32 No. 8 p.1109 ~ p.1118
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Role of Protein Tyrosine Nitration in Neurodegenerative Diseases and Atherosclerosis
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Kim Kwang-Pyo
Lee Jung-Rok
Kim Jae-Kyung
Lee Soo-Jae
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Abstract
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Nitric oxide generates reactive nitrosative species, such as peroxynitrite (ONOO?) that may be involved in a number of diseases. ONOO? can mediate protein tyrosine nitration which causes structural changes of affected proteins and leads to their inactivation. Various proteomics and immunological methods including mass spectrometry combined with both liquid and 2-D PAGE, and immunodetection have been employed to identify and characterize nitrated proteins from pathological samples. This review presents the pahtobiological roles of the pathogenic posttranslational modification in neurodegenerative diseases and atherosclerosis.
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KEYWORD
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Tyrosine nitration, Peroxynitrite, Neurodegenerative diseases, Atherosclerosis
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