|
KMID : 0043320090320091179
|
|
Archives of Pharmacal Research
2009 Volume.32 No. 9 p.1179 ~ p.1184
|
|
|
Structural Modification of 5,7-Dimethoxyflavone from Kaempferia parviflora and Biological Activities
|
|
Chavi Yenjai
Suchana Wanich
Siripit Pitchuanchom
Bungon Sripanidkulchai
|
|
|
Abstract
|
|
|
|
5,7-Dimethoxyflavone, a major compound from Kaempferia parviflora, was used as a starting material for structural modification. Seven flavonoid derivatives have been synthesized from this flavone. Two new oxime derivatives 4 and 6 exhibited cytotoxicity against HepG2 cell linewith IC50 values of 36.38 and 25.34 μg/mL, respectively, and against T47D cell line with IC50 values of 41.66 and 22.94 μg/mL, respectively. Compound 7 showed cytotoxicity against HepG2 and T47D cell lines with IC50 values of 21.36 and 25.00 μg/mL, respectively. Compounds 6 and 7 showed cytotoxicity nearly equal to the tamoxifen standard. In addition, oxime 6 exhibited antifungal activity against Candida albicans with an IC50 value of 48.98 μg/mL.
|
|
|
KEYWORD
|
|
|
Kaempferia parviflora, Oxime derivatives, Antifungal, Antimalarial, Cytotoxicity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|