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KMID : 0043320090320101393
Archives of Pharmacal Research
2009 Volume.32 No. 10 p.1393 ~ p.1397
Chromone Glycosides and Hepatoprotective Constituents of Hypericum erectum
Kim Youn-Chul

An Ren-Bo
Jeong Gil-Saeng
Beom Jin-Seon
Sohn Dong-Hwan
Abstract
Two chromone glycosides, hyperimone A [7-(¥â-D-glucopyranosyloxy)-5-hydroxy-2-(1-methylethyl)-4H-1-benzopyran-4-one (1)] and hyperimone B [7-(¥â-D-glucopyranosyloxy)-5-hydroxy-3-methyl-4H-1-benzopyran-4-one (2)], together with six known compounds were isolated from the methanolic extract of the whole plant of Hypericum erectum. 1,3,5,6-Tetrahydroxyxanthone (5) and I3, II8-biapigenin (6) showed moderate hepatoprotective activity with EC50 values of 160.2 ¡¾ 0.6 ¥ìM and 217.7 ¡¾ 1.3 ¥ìM, respectively, against tacrine-induced cytotoxicity in HepG2 cells.
KEYWORD
Hypericum erectum, Guttiferae, Hepatoprotective activity, Chromone glycosides, Hyperimone A, Hyperimone B
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