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KMID : 0043320090320101417
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Archives of Pharmacal Research
2009 Volume.32 No. 10 p.1417 ~ p.1423
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Orthogonal Array Design for Antidepressant Compatibility of Polysaccharides from Banxia-Houpu Decoction, a Traditional Chinese Herb Prescription in the Mouse Models of Depression
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Kong Ling-Dong
Yi Li-Tao
Zhang Li
Ding An-Wei
Xu Qun
Zhu Qin
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Abstract
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The present study investigated antidepressant-like interaction of five herb polysaccharide fractions from Banxia-Houpu decoction, composed of rhizome pinelliae (PRP), magnolia bark (PMB), poria (PPO), ginger rhizome (PGR) and folium perillae (PFP) by a L16(25) orthogonal array design with a two-factor interaction in the tail suspension and forced swimming and tests (TST, FST) in mice. Serotonin (5-HT) and dopamine (DA) levels in whole mouse brain were simultaneously examined after the FST exposure. Polysaccharides PMB, PPO, PFP, and interactions of PRP × PGR, PMB × PFP, PPO × PFP reduced immobility in the mouse FST. Furthermore, PMB and PPO were two principal components of polysaccharides elevating brain 5-HT levels. PFP was an adjuvant component elevating brain DA levels. These results demonstrated that ineffective PRP exhibited antidepressant-like effects when combined with another ineffective PGR, and PFP played a role in assisting effects of PMB and PPO. Therefore, PMB × PFP and PPO × PFP interactions on antidepressant-like effects were the cores in compatibility of polysaccharides from Banxia-Houpu decoction by attenuating abnormalities in the serotonergic and dopaminergic system functions in animal models of depression.
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KEYWORD
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Banxia-Houpu decoction, Polysaccharides, Orthogonal array design, Compatibility, Behavioral tests, Monoamine neurotransmitters
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