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KMID : 0043320090320121695
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Archives of Pharmacal Research
2009 Volume.32 No. 12 p.1695 ~ p.1698
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A New C29-sterol with a Cyclopropane Ring at C-25 and 26 from the Vietnamese Marine Sponge Ianthella sp.
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Kim Young-Ho
Tung Nguyen Huu
Minh Chau Van
Kiem Phan Van
Huong Hoang Thanh
Ha Tran-Thu
Dat Nguyen-Tien
Nhiem Nguyen Xuan
Cuong Nguyen Xuan
Hyun Jae-Hee
Kang Hee-Kyoung
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Abstract
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One new C29 sterol with a cyclopropane ring at C-25 and C-26, aragusteroketal B (1), and aragusterol B (2) were isolated from the Vietnamese marine sponge Ianthella sp. Their structures were elucidated by extensive spectroscopic analyses. Both 1 and 2 showed moderate cytotoxic activity against MCF-7, SK-Hep-1, and HeLa cell lines with IC50 in the range of 12.8-27.8 μM.
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KEYWORD
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Sponge, Ianthella sp., Sterol, Aragusteroketal B, Cytotoxic activity
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