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KMID : 0043320100330010005
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Archives of Pharmacal Research
2010 Volume.33 No. 1 p.5 ~ p.15
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An Efficient Synthesis and Antioxidant Properties of Novel Imino and Amino Derivatives of 4-Hydroxy Coumarins
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Neda Niciforovic
Nenad Vukovic
Slobodan Sukdolak
Slavica Solujic
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Abstract
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Series of imino and amino derivatives of 4-hydroxy coumarins were synthesized via conventional and microwave promoted procedure and evaluated for antioxidant potential through different in vitro models such as (DPPH) free radical scavenging activity, linoleic acid emulsion model system, reducing power assay and phosphomolybdenum method. All prepared compounds possess good antioxidant activity and among them p-nitro-phenyl derivative 6c with IC50 at 25.9 μM possesses radical scavenging activity which is comparable to standard BHT, while the best reducing power was observed in a case of benzyl amino compound 8c (RP50 255.6 μM). Also, observed data indicated that compounds may serve as inhibitors of lipid peroxidation process.
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KEYWORD
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4-Hydroxy coumarin, Imines, Amines, Antioxidant activity
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