|
KMID : 0043320100330060881
|
|
Archives of Pharmacal Research
2010 Volume.33 No. 6 p.881 ~ p.887
|
|
|
Ferilnic Nirate Produces Delayed Preconditioning Against Myocardial Ischemia and Reperfusion Injury in Rats
|
|
Wang Zhan-Qing
Xu Jing-Feng
Wang Jin-Ping
|
|
|
Abstract
|
|
|
|
To determine whether ferilnic nirate (FLNT) can precondition the rat heart against myocardial ischemia/reperfusion (I/R) damage and its mechanism, two groups of experiments were conducted. In the first group of experiments, rats were divided among four treatment groups: sham group; solvent with I/R (I/R control group); FLNT pretreatment with I/R (I/R FLNT group); and late ischemic preconditioning group (LPC group). In the second group of experiments without I/R, rats were divided into two treatment groups: control group and FLNT group. The results indicated that myocardial infarct size and the levels of creatine kinase and lactate dehydrogenase in the sera of the I/R FLNT group were significantly lower and the level of nitric oxide molecule and Mn-containing superoxide dismutase were significantly elevated in the heart tissue compared with I/R control group. The protein expression ratio of Bcl- 2/Bax in heart tissue was significantly elevated in the I/R FLNT group. These results demonstrate FLNT is able to precondition rat hearts against myocardial ischemia/reperfusion damage to a similar level as that achieved via the late phase of ischemic preconditioning. The mechanism may involve the up-regulation of nitric oxide and the strengthening of anti-oxidant and anti-apoptosis cellular functions.
|
|
|
KEYWORD
|
|
|
Nitric oxide, Ischemic preconditioning, Anti-oxidant, Anti-apoptosis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|