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KMID : 0043320100330111735
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Archives of Pharmacal Research
2010 Volume.33 No. 11 p.1735 ~ p.1739
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A piperidine alkaloid and limonoids from Arisaema decipiens, a traditional antitumor herb used by the dong people
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Zhao Fu Wei
Luo Min
Wang Yue Hu
Li Ma Lin
Tang Gui Hua
Long Chun Lin
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Abstract
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A new piperidine alkaloid and three known tetranortriterpenoids were isolated from the methanol extracts of the rhizomes of Arisaema decipiens Schott (Araceae) and their chemical structures were identified as (-)-(2R*,3S*,6S*)-N,2-dimethyl-3-hydroxy-6-(9-phenylnonyl) piperidine (1), 6-deacetylnimbin (2), 28-deoxonimbolide (3) and nimbin (4). The N-methylated derivative (1a) of 1 was synthesized. Compound 1 exhibited weak inhibitory activity against the MCF-7 cell line, while compound 1a showed potential inhibitory activity against the MCF-7 cell line with an IC50 value of 4.6 μM and weak inhibitory activity against K562 and SK-OV-3 cells. This plant in genus Arisaema is firstly reported as the source of limonoids that are considered a natural antitumor herbal medicine.
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KEYWORD
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Araceae, Arisaema decipiens Schott, (-)-(2R*, 3S*, 6S*)-N, 2-Dimethyl-3-hydroxy-6-(9-phenylnonyl), Limonoids, Antitumor activity
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